August 2015 – Dr. Wade McKenna

Case report of non-healing surgical wound treated with dehydrated human amniotic membrane

Dr. Riordan and Dr. McKenna recently published this case study demonstrating how amniotic tissue products promote wound healing. You can view the original article on the Journal of Translational Medicine website: Case report of non-healing surgical wound treated with dehydrated human amniotic membrane.

Authors
Neil H Riordan, Ben A George, Troy B Chandler, Randall W McKenna

Abstract

INTRODUCTION
Non-healing wounds can pose a medical challenge as in the case of vasculopathic venostasis resulting in a surgical ulcer. When traditional approaches to wound care fail, an amniotic patch (a dehydrated tissue allograft derived from human amnion) can function as a biologic scaffold to facilitate and enhance tissue regeneration and rehabilitation.

BACKGROUND
Amniotic AlphaPatches contain concentrated molecules of PGE2, WNT4, and GDF-11 which have angiogenic, trophic, and anti-inflammatory effects on tissues that may be useful in enhancing wound healing.

AIM-CASE REPORT
We present a case of a severe non-healing surgical wound in a 78-year-old male 17 days post right total knee arthroplasty. The full-thickness wound exhibited a mobile flap, measured 4 cm long × 3 cm wide, and showed undermining down to patellar tissue. We treated the wound conservatively for 6 weeks with no evidence of wound healing. Upon failure of the conservative treatment, two amniotic AlphaPatch (Amniotic Therapies, Dallas, TX, USA) were applied to the wound, and the wound healed completely in 10 weeks.

METHODS
In the OR, the wound was irrigated with three liters of double antibiotic solution under pulse lavage. Two dry amniotic AlphaPatch (4 cm × 4 cm) were placed over the wound with Acticoat applied on top.

RESULTS
At the two-week follow-up visit (following the incision and drainage of the wound dehiscence and application of the amniotic AlphaPatch), a central scab had formed centrally in the wound dehiscence area. At the four-week follow-up visit, the wound dehiscence area had completely scabbed over with no open areas left. At the eight-week follow-up visit, the scab had just fallen off, and the wound was healing well with immature skin representing the size of a penny. At the ten-week follow-up visit, the wound was completely healed.

DISCUSSION/CONCLUSION
Sterile, dehydrated amniotic tissue AlphaPatches (containing trophic factors known to enhance wound healing) have proven effective in completely healing an otherwise non-healing wound in a 78-year-old male who failed six weeks of conservative wound care treatment.

Patient Testimonial – Jennifer Wininger Ziegler

“As many of you know I had stem cell therapy for MS in 2012. In 2014 I had platelet rich plasma injections in my heel for plantar fasciitis with a full recovery! This past year I had an ACL injury after a skiing accident. Traditional surgery offered me a 9 month recovery time. NOT ACCEPTABLE! I’m a busy girl! Using a bone marrow aspirate taken from my hip and AlphaGems, Dr. McKenna had me hiking, biking, walking and enjoying life after 1 month! Total recovery in 6 weeks! This is my doctor, Dr. R Wade Mckenna talking about the increasing use of Stem Cell Therapy changing the way orthopedic surgeons treat patients. As we age, the wheels do start to fall off! HA! So if you have a knee injury, back problems, or an orthopedic condition of any kind, I can’t recommend the Riordan-McKenna Institute in Southlake, Tx. enough! I’ve chosen my own cells 3 times now! It’s a total ‪#‎NoBrainer‬! ‪#‎ChooseYourOwnCells‬ every time!” –Jennifer Wininger Ziegler

Patient Testimonial – Dr. Ted Margo

Patient Testimonial from Dr. Ted Margo:

From one surgeon to another:
I just got home from a procedure at RMI with Dr McKenna. I had bone marrow aspirate harvested and injected into my torn rotator cuff in my right shoulder. As a physician, I am keenly aware of what makes good doctors good doctors and good people good people. I can’t say enough about the warm and personal care I received today. From the front office staff, to the OR staff, to anesthesia and Dr McKenna everyone met or exceeded my expectations. Whenever I need medical care, especially surgical care, I look for a warm, loving demeanor, a feeling that my doctor and staff care about me personally and that I am important to them, and an exceptionally smart, talented surgeon who inspires and exudes confidence, a sense of personal excellence, and optimism. I received all of this today. Thanks to all of you at RMI who took such special care of me. Thanks a ton Wade.
Ted Margo, MD