Biologic Therapies – Dr. Wade McKenna

Study on Compensated Rotator Cuff Tear Arthropathy by Orthopedic Surgeon and Stem Cell Specialist, Wade McKenna, DO Published in Techniques in Shoulder and Elbow Surgery

Study on Compensated Rotator Cuff Tear Arthropathy by Orthopedic Surgeon and Stem Cell Specialist, Wade McKenna, DO Published in Techniques in Shoulder and Elbow Surgery

Dallas-Fort Worth, Texas (PRWEB) November 08, 2015

A Study by orthopedic surgeon and stem cell specialist, Dr. Wade McKenna of the Riordan-McKenna Institute entitled, “Outpatient Treatment of Compensated Cuff Arthropathy Using Inlay Arthroplasty With Subscapularis Preservation” is published in the December edition of Techniques in Shoulder and Elbow Surgery.

Picture of Wade McKenna, DO

Dr. McKenna is co-founder and chief medical officer of the Riordan-McKenna Institute of Regenerative Orthopedics (RMI) in Southlake, Texas. Co-author of this work is Troy Chandler, PA-C from North Central Texas Orthopedics in Decatur, Texas.

Rotator cuff tear arthropathy sometimes develops in patients who have had a very large, long-standing rotator cuff injury. In CTA, changes in the shoulder due to the rotator cuff tear cause arthritis and lead to destruction of joint cartilage.

The Shoulder HemiCAP® restoration procedure is designed to match the shape and contour of individual patient’s cartilage and joint surface and be an ideal alternative to shoulder replacement. It simply recreates a smooth surface where the cartilage has worn away — similar to a filling for a tooth cavity.

The study examined a consecutive series of 50 CTA patients treated by Dr. McKenna from 2007 to 2015. It concluded that resurfacing the humeral head (shoulder bone) using a HemiCAP shoulder implant preserves the joint and avoids bone loss and complications associated with more invasive procedures like stemmed arthroplasty or total shoulder replacement.

Furthermore, the HemiCAP procedure disrupts the degenerative cycle of early-stage CTA, effectively addresses causes of pain, and avoids further muscle imbalance. The latter is achieved by a special deltoid muscle-splitting approach that leaves the tendon under the shoulder bone intact.

All of these advantages resulted in accelerated recovery and rehabilitation for patients.

“We are very pleased with the positive outcome of this study. Although we specialize in non-surgical stem cell interventions at RMI, sometimes, as in the case of CTA, surgical intervention is indicated. That’s why it’s important for patients to seek out an experienced orthopedic surgeon who, in addition to orthopedic expertise, is well versed on the latest advances in stem cell therapy. A surgeon needs both to know when stem cell therapy may be effective and when surgery, perhaps augmented with biologics like bone marrow aspirate concentrate (BMAC) and AlphaGEMS amniotic tissue product, is a better option,” commented Dr. McKenna.

About Riordan-McKenna Institute (RMI)

RMI specializes in non-surgical treatment of acute and chronic orthopedic conditions using *AlphaGEMS flowable amniotic tissue allograft and bone marrow aspirate concentrate (BMAC) that is harvested using the patented BioMAC bone marrow aspiration cannula. Common conditions treated include meniscal tears, ACL injuries, rotator cuff injuries, runner’s knee, tennis elbow, and joint pain due to degenerative conditions like osteoarthritis. RMI also uses AlphaPATCH amniotic membranes as part of a complete wound care treatment regimen.

RMI also augments orthopedic surgeries with BMAC and AlphaGEMS to promote better post-surgical outcomes.

BMAC contains a patient’s own mesenchymal stem cells (MSC,) hematopoietic stem cells (CD34+), growth factors and other progenitor cells. AlphaGEMS is composed of collagens and other structural proteins, which provide a biologic matrix that supports angiogenesis, tissue growth and new collagen during tissue regeneration and repair.

*AlphaGEMS and AlphaPATCH products are produced by Amniotic Therapies Inc. from donated amniotic tissue after normal healthy births. For more information about AlphaGEMS, please visit: http://www.rmiclinic.com/non-surgical-stem-cell-injections-joint-pain/stemnexa-protocol/

http://www.rmiclinic.com

801 E. Southlake Blvd.

Southlake, Texas

76092

Tel: (817) 776-8155

Toll Free: (877) 899-7836

Fax: (817) 776-8154

For the original version on PRWeb visit: http://www.prweb.com/releases/2015/11/prweb13068117.htm

Abstract: The role of “cell therapy” in osteonecrosis of the femoral head

The role of “cell therapy” in osteonecrosis of the femoral head.

Originally posted on July 17.

Abstract
Background and purpose – The value of core decrompression for treatment of osteonecrosis of the femoral head (ONFH) is unclear. We investigated by a literature review whether implantation of autologous bone marrow aspirate, containing high concentrations of pluripotent mesenchymal stem cells, into the core decompression track would improve the clinical and radiological results compared with the classical method of core decompression alone. The primary outcomes of interest were structural failure (collapse) of the femoral head and conversion to total hip replacement (THR). Patients and methods – All randomized and non-randomized control trials comparing simple core decompression with autologous bone marrow cell implantation into the femoral head for the treatment of ONFH were considered eligible for inclusion. The methodological quality of the studies included was assessed independently by 2 reviewers using the Cochrane Collaboration tool for assessing risk of bias in randomized studies. Of 496 relevant citations identified, 7 studies formed the basis of this review. Results – The pooled estimate of effect size for structural failure of the femoral head favored the cell therapy group, as, in this treatment group, the odds of progression of the femoral head to the collapse stage were reduced by a factor of 5 compared to the CD group (odds ratio (OR) = 0.2, 95% CI: 0.08-0.6; p = 0.02). The respective summarized estimate of effect size yielded halved odds for conversion to THR in the cell therapy group compared to CD group (OR = 0.6, 95% CI: 0.3-1.02; p = 0.06). Interpretation – Our findings suggest that implantation of autologous mesenchymal stem cells (MSCs) into the core decompression track, particularly when employed at early (pre-collapse) stages of ONFH, would improve the survivorship of femoral heads and reduce the need for hip arthroplasty.

 

Read Full Article.

Abstract on Stem Cell Research from AlphaMedPress

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome

Originally posted on August 18

Abstract
: Mesenchymal stromal cells (MSCs) have been investigated as a treatment for various inflammatory diseases because of their immunomodulatory and reparative properties. However, many basic questions concerning their mechanisms of action after systemic infusion remain unanswered. We performed a detailed analysis of the immunomodulatory properties and proteomic profile of MSCs systemically administered to two patients with severe refractory acute respiratory distress syndrome (ARDS) on a compassionate use basis and attempted to correlate these with in vivo anti-inflammatory actions. Both patients received 2 × 106 cells per kilogram, and each subsequently improved with resolution of respiratory, hemodynamic, and multiorgan failure. In parallel, a decrease was seen in multiple pulmonary and systemic markers of inflammation, including epithelial apoptosis, alveolar-capillary fluid leakage, and proinflammatory cytokines, microRNAs, and chemokines. In vitro studies of the MSCs demonstrated a broad anti-inflammatory capacity, including suppression of T-cell responses and induction of regulatory phenotypes in T cells, monocytes, and neutrophils. Some of these in vitro potency assessments correlated with, and were relevant to, the observed in vivo actions. These experiences highlight both the mechanistic information that can be gained from clinical experience and the value of correlating in vitro potency assessments with clinical effects. The findings also suggest, but do not prove, a beneficial effect of lung protective strategies using adoptively transferred MSCs in ARDS. Appropriate randomized clinical trials are required to further assess any potential clinical efficacy and investigate the effects on in vivo inflammation.
SIGNIFICANCE:
This article describes the cases of two patients with severe refractory adult respiratory syndrome (ARDS) who failed to improve after both standard life support measures, including mechanical ventilation, and additional measures, including extracorporeal ventilation (i.e., in a heart-lung machine). Unlike acute forms of ARDS (such in the current NIH-sponsored study of mesenchymal stromal cells in ARDS), recovery does not generally occur in such patients.

Read Full Article.

Case report of non-healing surgical wound treated with dehydrated human amniotic membrane

Dr. Riordan and Dr. McKenna recently published this case study demonstrating how amniotic tissue products promote wound healing. You can view the original article on the Journal of Translational Medicine website: Case report of non-healing surgical wound treated with dehydrated human amniotic membrane.

Authors
Neil H Riordan, Ben A George, Troy B Chandler, Randall W McKenna

Abstract

INTRODUCTION
Non-healing wounds can pose a medical challenge as in the case of vasculopathic venostasis resulting in a surgical ulcer. When traditional approaches to wound care fail, an amniotic patch (a dehydrated tissue allograft derived from human amnion) can function as a biologic scaffold to facilitate and enhance tissue regeneration and rehabilitation.

BACKGROUND
Amniotic AlphaPatches contain concentrated molecules of PGE2, WNT4, and GDF-11 which have angiogenic, trophic, and anti-inflammatory effects on tissues that may be useful in enhancing wound healing.

AIM-CASE REPORT
We present a case of a severe non-healing surgical wound in a 78-year-old male 17 days post right total knee arthroplasty. The full-thickness wound exhibited a mobile flap, measured 4 cm long × 3 cm wide, and showed undermining down to patellar tissue. We treated the wound conservatively for 6 weeks with no evidence of wound healing. Upon failure of the conservative treatment, two amniotic AlphaPatch (Amniotic Therapies, Dallas, TX, USA) were applied to the wound, and the wound healed completely in 10 weeks.

METHODS
In the OR, the wound was irrigated with three liters of double antibiotic solution under pulse lavage. Two dry amniotic AlphaPatch (4 cm × 4 cm) were placed over the wound with Acticoat applied on top.

RESULTS
At the two-week follow-up visit (following the incision and drainage of the wound dehiscence and application of the amniotic AlphaPatch), a central scab had formed centrally in the wound dehiscence area. At the four-week follow-up visit, the wound dehiscence area had completely scabbed over with no open areas left. At the eight-week follow-up visit, the scab had just fallen off, and the wound was healing well with immature skin representing the size of a penny. At the ten-week follow-up visit, the wound was completely healed.

DISCUSSION/CONCLUSION
Sterile, dehydrated amniotic tissue AlphaPatches (containing trophic factors known to enhance wound healing) have proven effective in completely healing an otherwise non-healing wound in a 78-year-old male who failed six weeks of conservative wound care treatment.

Dr Wade McKenna Interview with Biologic Therapies

Originally Published in January 2012.

Over the last five years, R. Wade McKenna, DO, founder of North Central Texas Orthopedics and Sports Medicine of Decatur, Texas and McKenna Orthopedics of Trophy Club, Texas, has treated over 3,000 patients with point-of-care Autologous Biologic Therapy (ABT). ABT is the use of a patient’s own regenerative cells and other growth factors to promote and accelerate the body’s natural healing cascade. With the recent news of high profile athletes such as Alex Rodriguez, Kobe Bryant, Tiger Woods and Peyton Manning traveling overseas for similar treatment, we asked Dr. McKenna if this technology is unavailable or unapproved in the United States.

Dr. McKenna replies with a chuckle, “Neither of those assumptions is true. In fact, I began using point-of-care Autologous Biologic Therapy to aid in the healing of rotator cuff surgeries more than five years ago. My initial use of ABT was directed toward improving surgical results only in rotator cuff surgery. However, the positive effect the addition of this biologic therapy had on rotator cuff surgical outcomes was so impressive I began to expand the use of this novel treatment to other difficult-to-treat injuries and conditions. The only reason I can think of as to why these athletes went overseas is because they’ve never heard of my practice in Decatur, Texas.”

Wade-Holding-Drill-w-Bio-MA
Dr. Wade McKenna prepares to aspirate bone marrow with the Bio-MAC cannula.

The use of a patient’s own growth factors derived from platelet-rich plasma (PRP) has been a popular treatment for sports related ligament and tendon injuries. McKenna adds, “Initially the focus centered on the wound care market where PRP showed promising results. We began to understand the healing powers found in whole blood, and early adaptors such as myself incorporated the therapy into our patient care protocols. For Kobe Bryant and Alex Rodriguez, their treatments contained stem cells not found in whole blood. Most of the physicians in the U.S. don’t have experience in point-of-care Autologous Biologic Therapy so high-profile athletes such as these seek treatment with cultured stem cells in Europe.”

Both Bryant and Rodriguez were seeking a clinical culturing process of their own stem cells to achieve a desired number of these regenerative cells that would produce a positive outcome. In the U.S., the FDA has yet to approve stem cell culturing for the purpose of treating these injuries, causing most Americans to seeking this treatment to travel overseas.

In Decatur, Texas, Dr. McKenna uses a centrifuge to achieve similar large numbers of regenerative cells and administers them to his patients in an FDA approved point-of-care procedure. The processing is done while the patient is undergoing treatment for his/her injury and takes less than 25 minutes. In Europe the cells are cultured in a laboratory and administered to the patient two to three days later, which is a procedure that is not FDA approved.

The method Dr. McKenna uses to acquire a patient’s regenerative cells from his/her bone marrow does not require culturing. “I began utilizing regenerative cells in point-of-care treatments for orthopedic related complications over five years ago. Back then I was limited to surgical applications due to the archaic method of bone marrow harvest and the lack of a sophisticated processing device. The new Bio-MAC bone marrow aspiration cannula from Biologic Therapies changes all that,” says McKenna.

Previous to recent advances in technology by Biologic Therapies, Inc. (BTI), obtaining bone marrow aspirate was a difficult and painful process using a hammer-driven cannula (needle). “I was fortunate to have a business contact that was focused on bringing marrow harvesting and processing out of the dark ages. Together, we collaborated on designing a state-of-the-art harvesting device, the Bio-MAC Bone Marrow Aspiration Cannula, as well as developing a centrifuge system capable of concentrating millions of regenerative cells from the blood products in the harvested marrow. I’m very proud of our development and feel BTI’s Bio-MAC will revolutionize the emerging point-of-care Autologous Biologic Therapy market,” said McKenna.

Dr. McKenna has joined forces with Biologic Therapies of Ocala, Florida. “Biologic Therapies is our medical think tank,” explains McKenna. “We are now able to further the advancement of Autologous Biologic Therapy while promoting the business of point-of-care regenerative medicine. No other company I’m aware of combines the two.” Point-of-care refers to the process of harvesting regenerative cells from bone marrow and reintroducing those cells back into the patient is one, quick procedure without any culturing of the cells.

With the use of technology he developed with Biologic Therapies, Dr. McKenna has successfully drawn regenerative cells from the bone marrow of his patients in an in-office setting. These new advancements have made obtaining bone marrow aspirate and the use of regenerative cells a much easier and cost efficient point-of-care process.

One of the most innovative uses of bone marrow aspirate concentrate, which was pioneered by Dr. McKenna, involves treating arthritic knees. “Arthritis is technically just the absence of articular cartilage covering the joint surfaces. Many times small arthritic lesions develop which are called osteochondral defects. These defects often progress to severe changes involving the entire joint,” explains McKenna.

Currently, the standard of care for these osteochondral defects or arthritic lesions is a surgery called microfracture. In microfracture surgery an arthroscopic procedure is performed to create small fractures through the underlining cancellous bone to treat the defect. These small holes help promote healing by the liberation of small amounts of bone marrow within the joint.

“My initial thought involving this process was that if small drops of liberated bone marrow aided in healing of these lesions, what would the addition of active regenerative cells from concentrated bone marrow aspirate be capable of doing?” states McKenna. This thinking led to the development of a protocol to treat patients with not only isolated osteochondral lesions, but also to treat patients with more severe osteoarthritis.

Dr. McKenna adds, “The growth of articular cartilage is common in children as they develop into adults and cartilage volume increases. Unfortunately, the growth of articular cartilage in adults is rare and treatment for the loss of cartilage has been focused on replacing or fusing these arthritic joints.”

The use of Autologous Biologic Therapy in a solution of concentrated growth factors has brought new hope to patients suffering from worn out arthritic joints. “The procedures we are developing are very similar to the stem cell therapy procedure Kobe Bryant, Tiger Woods and Alex Rodriguez received in Europe. Our clinical results are showing a rejuvenation of the knee’s overall function. MRI and standing x-rays confirm the space between the bones (cartilage area) is increasing. It’s early in the development stage, but if my use of regenerative cells continues to produce such positive outcomes, it’s quite possible we will have developed a new standard of care for millions suffering from arthritis,” says McKenna.

I also wanted to know if high-profile athletes, or those dreaming of being one (weekend warriors), were the only people who will benefit from this emerging point-of-care regenerative medicine?

McKenna answers, “I believe that almost any patient undergoing surgery can expect improved surgical results with this technology. This is evidenced by the fact that the most frequent application of regenerative cells is found in spine surgery. Surgeons utilize the phenomenal healing characteristics of regenerative cells to increase the formation of bone and aid in the formation of the fusion mass. The results of spinal fusions have been dramatically improved with the use of regenerative cells derived from bone marrow aspirate concentrate.”

McKenna goes on to explain, “Fractures that fail to heal are called non-union fractures and this is one of the most challenging issues in orthopedic surgery. The use of regenerative cells to heal these fracture non-unions continues to evolve. I have used mesenchymal stem cells with great success to aid in the healing of non-union fractures involving the clavicle, tibia and metatarsal bones of the foot.”

As a trained Trauma specialist, Dr. McKenna takes Emergency Room calls and sees many broken hips. Most of these fractures occur in elderly women who suffer from osteoporosis. “The introduction of bone marrow aspirate concentrate to augment the fixation of hip fractures has, in my clinical experience, increased the viability of the femoral head. I have seen 80-year-old patients walk into my office following hip fracture surgery with a femoral head that, on x-ray, looks unaffected by their previous fracture. Prior to the use of bone marrow aspirate concentrate this result would be uncommon,” states McKenna.

As we concluded the interview Dr. McKenna added with a great voice of confidence, “Certainly the future of orthopedics and all the surgical subspecialties will involve the use of regenerative biologics like stem cells. Unlocking the body’s ability to heal itself is the real future of patient care. I am proud to be involved as an innovator in this emerging technology.”

Biologic Therapies Recieves 510(k) Clearance

Biologic Therapies Receives 510(k) Clearance for Bio-MAC and Bio-CORE Bone Marrow Aspiration Cannulas

Ocala, FL (May 12, 2015) – Biologic Therapies, a medical device company specializing in the design and development of products for regenerative medicine, today announced that it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for its Bio-MAC and Bio-CORE cannulas. The Bio-MAC Bone Marrow Aspiration Cannula and Bio-CORE Bone Marrow Biopsy Cannula are minimally invasive devices that are inserted into bone with any standard surgical drill.

5-Bio-MACs-Sizes-Logo                               Bio-MAC-Bio-CORE
                                                                         Bio-MAC Bone Marrow Aspiration Cannulas                             Bio-CORE Bone Marrow Biopsy Cannulas

Dr. Wade McKenna, Biologic Therapies’ Chief Medical Director, said, “Unlike traditional bone marrow aspiration cannulas, which are pounded into bone with a mallet or pushed in with brute force, the power driven Bio-MAC and Bio-CORE do not cause microfractures in the bone that can result in pain for the patient. Plus, the Bio-MAC and Bio-CORE are available in multiple lengths, which allow for fast and easy bone marrow draws throughout the anatomy. In addition to the iliac crest and lumbar vertebral body, the tibia, humerus and calcaneus are now viable sites for bone marrow aspiration.

“Our products enable physicians to aspirate bone marrow in their own office with only local anesthesia, which is revolutionary. The ability to aspirate a patient’s marrow, concentrate the marrow in a centrifuge to derive the maximum number of regenerative cells and growth factors, and then give the concentrated cells and growth factors back to the patient in a physician’s office makes regenerative cell therapy a much easier, more available and less costly procedure. The entire point-of-care procedure takes less than 30 minutes. Of course, the Bio-MAC and Bio-CORE are also used in hospitals and surgery centers.”

Autospin-sm         Autospin-Kit
AUTOSPIN Centrifuge                               AUTOSPIN BMAC Convenience Kit

For concentrating bone marrow Biologic Therapies offers its AUTOSPIN centrifuge and convenience kits. The AUTOSPIN is a fully automated dual spin centrifuge that can be programmed to deliver a volume of 3 to 10 ml from each processing cycle. It is a closed system, which dramatically reduces the chance for contamination. Two separate AUTOSPIN Convenience Kits contain all the components needed to process Bone Marrow Aspirate Concentrate (BMAC) or Platelet-Rich Plasma (PRP).

Luke Whalen, Biologic Therapies’ CEO, said, “My team and I are very pleased to receive 510(k) clearance for our Bio-MAC and Bio-CORE cannulas. We are currently expanding our business throughout the United States, Europe, India, China and South Africa. Biologic Therapies is improving the health of patients around the world by making our products the standard of care for regenerative medicine.”

About Biologic Therapies

Based in Ocala, Florida, Biologic Therapies, Inc. (www.biologictherapies.com) (www.amniotictherapies.com) develops innovative technologies to meet the needs of the emerging regenerative medicine segment of the healthcare market. Biologic Therapies’ mission is to provide groundbreaking medical technologies and procedures that significantly enhance the body’s natural healing ability, thereby providing patients with improved outcomes and quicker restoration of function.

 

Biologic Therapies Conducts Stem Cell Training at Andrews Institute

Biologic Therapies Conducts Stem Cell Training at Andrews Institute

Ocala, FL (October 23, 2014) – It was announced today that a team from Biologic Therapies, Inc. (BTI) conducted a two-day stem cell therapy presentation and hands-on training and education seminar at the Andrews Institute for Orthopaedics & Sports Medicine in Gulf Breeze, Florida. Andrews Institute physicians and nursing staff were trained on the proper surgical techniques and operational procedures for Biologic Therapies’ Bio-MAC Bone Marrow Aspiration Cannula and Bio-SPIN Autologous Platelet Separator centrifuge.

Left to right: Dr. Wade McKenna, Biologic Therapies’ Chief Medical Director, and Dr. James Andrews, founder of the Andrews Institute for Orthopaedics & Sports Medicine, discuss Biologic Therapies’ new technologies for stem cell therapy.
Left to right: Dr. Wade McKenna, Biologic Therapies’ Chief Medical Director, and Dr. James Andrews, founder of the Andrews Institute for Orthopaedics & Sports Medicine, discuss Biologic Therapies’ new technologies for stem cell therapy.

The purpose of the presentation and training seminar was to enhance relations with the Andrews Institute by providing up-to-date information on the science of stem cell therapy and by educating physicians and nursing staff on Biologic Therapies’ products and procedures for aspirating bone marrow and concentrating stem cells in the marrow through centrifugation.

“A very positive part of this event has been developing personal relationships with doctors and nurses from the world-renowned Andrews Institute. We are now working together as a team to deliver stem cell therapy using what I believe are the most advanced products and techniques available today,” said Luke Whalen, Biologic Therapies’ CEO.

Being able to work toward a common goal of helping patients through biologics and regenerative medicine is essential to Biologic Therapies’ overall mission, as is providing the products and procedural knowledge to treat injuries.

During the first day of the seminar, Andrews Institute doctors and nurses were given a presentation titled ‘Clinical update and rationale on the use of biologic therapy in the surgical arena: Bone Marrow Aspirate Concentrate’ by Dr. Wade McKenna, Biologic Therapies’ Chief Medical Director. Dr. McKenna presented some of the latest information on the science of stem cell therapy as well as numerous examples of his own successful results from the application of stem cells in bone marrow aspirate concentrate.

Following Dr. McKenna’s presentation, over 30 members of the Andrews Institute nursing staff attended a hands-on training session

Members of Biologic Therapies’ team included, left to right: Zac Collins, Quality Assurance Manager & Chief Design Engineer; Luke Whalen, CEO; Scott Reynolds, Vice President of Marketing; Jennifer Kobel, Account Manager; and Jeff Reavis, Sales Manager.
Members of Biologic Therapies’ team included, left to right: Zac Collins, Quality Assurance Manager & Chief Design Engineer; Luke Whalen, CEO; Scott Reynolds, Vice President of Marketing; Jennifer Kobel, Account Manager; and Jeff Reavis, Sales Manager.

on how to concentrate bone marrow in Biologic Therapies’ Bio-SPIN Autologous Platelet Separator centrifuge. The session included a short presentation, one-on-one training instruction given by Biologic Therapies personnel, and a follow-up quiz to test the nurses’ knowledge of the procedure. All nurses passed the quiz and were awarded Continuing Education Units (CEUs).
On the second day of event, Dr. McKenna provided a hands-on training session for Andrews Institute physicians on how to use Biologic Therapies’ Bio-MAC Bone Marrow Aspiration Cannula. Using a cadaver, Dr. McKenna demonstrated the proper procedures for using a surgical power drill to drive the Bio-MAC cannula into the anterior iliac crest and proximal tibia bones from which marrow can be aspirated.

After Dr. McKenna’s demonstration, all attending Andrews Institute physicians were given the opportunity to use the Bio-MAC with the same iliac crest and tibia bones. Many physicians remarked how easy it was to use the minimally invasive Bio-MAC and that it was a definite improvement over other traditional devices designed for marrow aspiration.

“They welcomed us and seemed very appreciative of what we have done with our products and procedures for stem cell therapy,” said Dr. McKenna. “They asked a lot of questions about how to get the maximum number of stem cells from a bone marrow draw, and we were happy to explain and demonstrate the answers.”

Dr. Wade McKenna giving a presentation to Andrews Institute physician and nursing personnel.
Dr. Wade McKenna giving a presentation to Andrews Institute physician and nursing personnel.

The training and education seminar was part of Biologic Therapies’ ongoing initiative to train physicians and nurses worldwide. A similar presentation and demonstration was given in Vienna, Austria in May of this year.


 

About Biologic Therapies

Based in Ocala, Florida, Biologic Therapies, Inc. (www.biologictherapies.com), is a company with a principal strategy of seeking out and developing innovative, proprietary and patented technologies to meet the needs of the rapidly emerging science of biologics and regenerative medicine, including stem cell therapy. Biologic Therapies provides groundbreaking medical technologies that significantly enhance the body’s natural healing ability, thereby providing patients with improved outcomes and quicker restoration of function. The Company’s products provide access to the biologics / regenerative medicine sector of the healthcare market.

About Andrews Institute for Orthopaedics & Sports Medicine

Members of the Andrews Institute’s physician and nursing staff attend a presentation given by Dr. Wade McKenna.
Members of the Andrews Institute’s physician and nursing staff attend a presentation given by Dr. Wade McKenna.

World–class athletes, weekend warriors, youth athletes and everyday people have access to state–of–the–art performance training

and health care services at the Andrews Institute for Orthopaedics & Sports Medicine (www.andrewsinstitute.com) in Gulf Breeze, Florida.
Under the leadership and reputation of internationally renowned orthopaedic sports surgeon Dr. James Andrews, the Andrews Institute provides a spectrum of services in order for patients to quickly and accurately address their orthopaedic needs.

Encompassing nearly 127,000 square feet, the Andrews Institute is filled with dedicated research laboratories as well as education and conference facilities plus its numerous multi–specialty clinical departments to compliment the services of its 40 affiliated physicians to provide an all–inclusive continuum of care. The Andrews Institute mission is to provide the best medical care for the musculoskeletal system, using the latest innovative clinical and surgical technologies, and to improve patient care through research and education with an emphasis on prevention.

Stem Cells Successfully Treat Chronic Achilles Tendon Injury

 

Stem Cells Successfully Treat Chronic Achilles Tendon Injury

timthumb (1)Ocala, FL (October 7, 2014) – Biologic Therapies, Inc. (BTI), a company that specializes in the design and development of medical devices and procedures for the regenerative medicine market, announced today that its products have been used to successfully treat a chronically injured Achilles tendon with stem cell therapy.

A case report, titled ‘Minimally Invasive Autologous Bone Marrow Concentrate Stem Cells in the Treatment of the Chronically Injured Achilles Tendon: A Case Report’, was authored by Biologic Therapies’ Chief Medical Director, Dr. R. Wade McKenna, and Chief Scientific Officer, Dr. Neil H. Riordan, founders of the Riordan-McKenna Institute in Southlake, Texas, USA (www.rmiclinic.com).

The case involved a 56-year-old female patient complaining of a painful “knot” in her left Achilles tendon. The pain limited her ability to perform daily activities such as shopping or being up on her feet for longer than 30 minutes. She had been an active tennis player and recreational athlete, but had not been able to play tennis or jog for ten years. She reported significant pain when relaxing and great pain when walking. The patient had been to multiple physicians and had followed ten years of standard treatment with stretches and anti-inflammatories. She refused multiple offers of invasive surgery that could not promise a return to tennis.

On physical examination by Dr. R. Wade McKenna, the patient had a large, palpable knot in the Achilles tendon, very noticeable and acutely tender. An MRI scan showed severe hypertrophic changes with marked tendinopathy.

The patient received a point-of-care stem cell therapy treatment in Dr. McKenna’s office as an outpatient procedure using Biologic Therapies products. The physician drew bone marrow from her tibia (shin) bone, processed the marrow in a centrifuge to concentrate the stem cells and growth factors, then injected the stem cells and growth factors into and around her injured Achilles tendon. Prior to the injection of the concentrated stem cells and growth factors, an injection of local anesthesia was given to prevent pain. The patient reported little to no pain during or after the procedure.

After six weeks the patient reported no pain at rest and minimal pain while walking. After eight weeks, there was even less pain while walking. The knot was less than 50% of the pre-treatment size and was relatively non-tender to touch. She was back to playing tennis without significant pain or difficulty. After ten weeks the patient was doing much better. An MRI scan showed even more reduction in the size of the knot, and pain was reduced even further. After 32 weeks an MRI scan showed near complete healing of the treated Achilles tendon.

The case report has been published by the scientific journal, CELLR4, the Official Journal of The Cure Alliance. The report can be seen on the CELLR4 website at www.cellr4.org/article/1100.
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According to Luke Whalen, Biologic Therapies’ CEO, “This is an extremely important development for Biologic Therapies. Not only does theThe clinical case report shows that stem cell therapy really does workis an effective treatment for chronic , we can now prove that it works in an application like a damaged Achilles tendon injury, which has not been documented before. The report also shows that stem cell therapy for this type of injury can be treated administered in a physician’s office as an a point-of-care outpatient procedure using Biologic Therapies products. There is no need for hospitalization and surgery as would have been the case previously.

“AnThe other very important aspect of the publishing publication of this case study report is that the scientific journal it was published by is one of the most prestigious publications in the regenerative medicine industry. The members of the CELLR4 Journal Editorial Board that reviewed and approved our the study report are literally the ‘who’s who’ of regenerative medicine professionals from around the world. We are very honored that they chose to publish our the clinical studyreport. This helps to reinforce. “Additionally, this clinical study is just the first of many studies that we are in the process of completing. The publication of this first study and future clinical studies will certainly help Biologic Therapies’ to reinforce its position as a global leader in regenerative medicine,” said Whalen.

The CELLR4 Editorial Board is led by Editor in Chief, Camillo Ricordi
from the Cell Transplant Center and Diabetes Research Institute at the University of Miami, Miami, Florida, USA. Other editorial staff of note include the Associate Editor for Asia, Jianming Tan
of Fuzhou General Hospital, Xiamen University, China; Assistant Editor, Antonello Pileggi of the Cell Transplant Center and Diabetes Research Institute at the University of Miami, Miami, Florida, USA; and Assistant Board member Arnold I. Caplan
from Case Western Reserve University, Cleveland, Ohio, USA.

In the late 1980’s, Dr. Arnold Caplan and colleagues developed and patented the technology to isolate adult human mesenchymal stem cells (MSCs) from human bone marrow and to preserve their multi-potency (Caplan et al., 2001; Koc et al., 1999; Lennon et al., 2006). Adult human MSCs are capable of differentiating into a number of tissue types including bone, cartilage, muscle, marrow, tendon, ligament, adipocytes, and connective tissue.

A complete listing of theOver over 100 members scientists, physicians, researchers and educators from around the world make up of the CELLR4 Editorial Board from around the world. A complete listing of the Board members can be found online at http://www.cellr4.org/editorial-board


About CELLR4

CellR4 CELLR4 (http://www.cellr4.org) is a scientific journal with particular focus on cellular repair, replacement, regeneration, reprogramming and differentiation. Its scope ranges from fundamental new discoveries in basic science to translational, clinical trials and delivery of novel therapeutic options. As the official journal of the international non-profit organization The Cure Alliance, CellR4 CELLR4 serves as a platform for discussion of challenges and opportunities on the path to the development of new treatments, independently from the disease target. CellR4 CELLR4 also publishes commentaries and opinion papers on regulatory, legal, and ethical issues, as well as information on global collaborative platforms and funding opportunities of interest to the field.

CELLR4 also serves as the official journal of the Fondazione Cure Alliance Onlus, another non-profit international organization that include physicians, scientists, patients, patient advocates, business and philanthropy leaders, with the mission to promote collaborative efforts worldwide, while addressing and working to resolve impediments and challenges on the path to develop cures for diseases now afflicting humankind. In this direction, the publication also serves as a shared communication platform to discuss challenges and opportunities on the path to develop new treatments.

About Biologic Therapies

Based in Ocala, Florida, Biologic Therapies, Inc. (www.biologictherapies.com), is a company with a principal strategy of seeking out and developing innovative, proprietary and patented technologies to meet the needs of the rapidly emerging science of regenerative medicine, including stem cell therapy. Biologic Therapies provides groundbreaking medical technologies that significantly enhance the body’s natural healing ability, thereby providing patients with improved outcomes and quicker restoration of function. The Company’s products provide access to the biologics / regenerative medicine sector of the healthcare market.

Stem Cells Used to Successfully Treat Chronic Achilles Tendon Injury

Originally posted on October 6, 2o14

Ocala, FL, October 06, 2014 –(PR.com)-Biologic Therapies, Inc. (BTI), a company that specializes in the design and development of medical devices and procedures for the regenerative medicine market, announced today that its products have been used to successfully treat a chronically injured Achilles tendon with stem cell therapy.

A case report, titled ‘Minimally Invasive Autologous Bone Marrow Concentrate Stem Cells in the Treatment of the Chronically Injured Achilles Tendon: A Case Report’, was authored by Biologic Therapies’ Chief Medical Director, Dr. R. Wade McKenna, and Chief Scientific Officer, Dr. Neil H. Riordan, founders of the Riordan-McKenna Institute in Southlake, Texas, USA (www.rmiclinic.com).

The case involved a 56-year-old female patient complaining of a painful “knot” in her left Achilles tendon. The pain limited her ability to perform daily activities such as shopping or being up on her feet for longer than 30 minutes. She had been an active tennis player and recreational athlete, but had not been able to play tennis or jog for ten years. She reported significant pain when relaxing and great pain when walking. The patient had been to multiple physicians and had followed ten years of standard treatment with stretches and anti-inflammatories. She refused multiple offers of invasive surgery that could not promise a return to tennis.

On physical examination by Dr. R. Wade McKenna, the patient had a large, palpable knot in the Achilles tendon, very noticeable and acutely tender. An MRI scan showed severe hypertrophic changes with marked tendinopathy.

The patient received a point-of-care stem cell therapy treatment in Dr. McKenna’s office as an outpatient procedure using Biologic Therapies products. The physician drew bone marrow from her tibia (shin) bone, processed the marrow in a centrifuge to concentrate the stem cells and growth factors, then injected the stem cells and growth factors into and around her injured Achilles tendon. Prior to the injection of the concentrated stem cells and growth factors, an injection of local anesthesia was given to prevent pain. The patient reported little to no pain during or after the procedure.

After six weeks the patient reported no pain at rest and minimal pain while walking. After eight weeks, there was even less pain while walking. The knot was less than 50% of the pre-treatment size and was relatively non-tender to touch. She was back to playing tennis without significant pain or difficulty. After ten weeks the patient was doing much better. An MRI scan showed even more reduction in the size of the knot, and pain was reduced even further. After 32 weeks an MRI scan showed near complete healing of the treated Achilles tendon.

The case report has been published by the scientific journal, CELLR4, the Official Journal of The Cure Alliance. The report can be seen on the CELLR4 website athttp://www.cellr4.org/article/1100.

According to Luke Whalen, Biologic Therapies’ CEO, “This is an extremely important development for Biologic Therapies. The case report shows that stem cell therapy is an effective treatment for chronic Achilles tendon injury, which has not been documented before. The report also shows that stem cell therapy for this type of injury can be administered in a physician’s office as a point-of-care outpatient procedure using Biologic Therapies products. There is no need for hospitalization and surgery as would have been the case previously.

“Another important aspect of the publication of this case report is that the scientific journal it was published by is one of the most prestigious publications in the regenerative medicine industry. The members of the CELLR4 Journal Editorial Board that reviewed and approved the report are literally the ‘who’s who’ of regenerative medicine professionals from around the world. We are honored that they chose to publish the report. This helps to reinforce Biologic Therapies’ position as a global leader in regenerative medicine,” said Whalen.

The CELLR4 Editorial Board is led by Editor in Chief, Camillo Ricordi
from the Cell Transplant Center and Diabetes Research Institute at the University of Miami, Miami, Florida, USA. Other editorial staff of note include the Associate Editor for Asia, Jianming Tan
of Fuzhou General Hospital, Xiamen University, China; Assistant Editor, Antonello Pileggi of the Cell Transplant Center and Diabetes Research Institute at the University of Miami, Miami, Florida, USA; and Assistant Board member Arnold I. Caplan
from Case Western Reserve University, Cleveland, Ohio, USA.

In the late 1980’s, Dr. Arnold Caplan and colleagues developed and patented the technology to isolate adult human mesenchymal stem cells (MSCs) from bone marrow and to preserve their multi-potency (Caplan et al., 2001; Koc et al., 1999; Lennon et al., 2006). Adult human MSCs are capable of differentiating into a number of tissue types including bone, cartilage, muscle, marrow, tendon, ligament, adipocytes, and connective tissue.

Over 100 scientists, physicians, researchers and educators from around the world make up the CELLR4 Editorial Board. A complete listing of the Board members can be found at http://www.cellr4.org/editorial-board

About CELLR4
CELLR4 (http://www.cellr4.org) is a scientific journal with particular focus on cellular repair, replacement, regeneration, reprogramming and differentiation. Its scope ranges from fundamental new discoveries in basic science to translational, clinical trials and delivery of novel therapeutic options. As the official journal of the international non-profit organization The Cure Alliance, CELLR4 serves as a platform for discussion of challenges and opportunities on the path to the development of new treatments, independently from the disease target. CELLR4 publishes commentaries and opinion papers on regulatory, legal, and ethical issues, as well as information on global collaborative platforms and funding opportunities of interest to the field.

CELLR4 also serves as the official journal of the Fondazione Cure Alliance Onlus, another non-profit international organization that include physicians, scientists, patients, patient advocates, business and philanthropy leaders, with the mission to promote collaborative efforts worldwide, while addressing and working to resolve impediments and challenges on the path to develop cures for diseases now afflicting humankind. In this direction, the publication serves as a shared communication platform to discuss challenges and opportunities on the path to develop new treatments.

About Biologic Therapies
Based in Ocala, Florida, Biologic Therapies, Inc. (www.biologictherapies.com), is a company with a principal strategy of seeking out and developing innovative, proprietary and patented technologies to meet the needs of the rapidly emerging science of regenerative medicine, including stem cell therapy. Biologic Therapies provides groundbreaking medical technologies that significantly enhance the body’s natural healing ability, thereby providing patients with improved outcomes and quicker restoration of function. The Company’s products provide access to the biologics / regenerative medicine sector of the healthcare market.